Polynucleotides are one of the most exciting developments in regenerative aesthetic treatment, offering deep rejuvenation by working at a cellular level. These innovative injectables help improve skin quality, stimulate the production of collagen and elastin, and enhance hydration—all without adding artificial volume. At our aesthetic clinic in Chiswick, polynucleotide treatments are gaining popularity among those seeking natural skin rejuvenation with long-term benefits.
Polynucleotide treatments involve injecting purified DNA fragments—the building blocks of DNA—into the skin to promote natural regeneration. These injections target ageing skin by stimulating fibroblasts, encouraging the production of collagen and elastin. The result is smoother, healthier, and more youthful skin with minimal downtime.
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At Chiswick Clinic, polynucleotide treatment is delivered in a medically-led and customised manner. Every individual’s skin is unique, and so every treatment plan is tailored accordingly. Whether you’re targeting fine lines, scars, or under-eye concerns, our consultation process ensures your injectable treatment journey is both safe and effective. We create the optimal environment for your treatment using the latest in skin rejuvenation science.
Polynucleotides are derived from purified salmon DNA, chosen for its close compatibility with human DNA. When polynucleotides are injected into the skin, they activate fibroblasts to stimulate the production of collagen and elastin, improving the skin’s structure and elasticity. Polynucleotides work at a cellular level to repair tissue, hydrate the skin, and support skin health.
The properties of polynucleotides help restore skin elasticity, reduce inflammation, and promote angiogenesis (new blood vessel formation), leading to better skin texture and glow. Polynucleotides are also anti-inflammatory, making them a great treatment for skin that is prone to redness, sensitivity, or post-treatment irritation.
Unlike a dermal filler, which adds volume, polynucleotides deliver regenerative effects. Polynucleotide injections focus on rebuilding and healing rather than filling. While skin boosters such as Profhilo are designed to hydrate and support skin elasticity, polynucleotides stimulate skin cells to regenerate and restore damaged or ageing tissue.
This makes polynucleotides ideal for individuals seeking natural enhancement and sustained improvement in skin health. When polynucleotides are injected around the eye area or other delicate regions, they typically do not cause puffiness or unnatural swelling, as some fillers might.
Polynucleotides can be used on the face, neck, décolletage, and hands. They are especially beneficial in the under-eye area, where the tissue is thin and prone to early signs of ageing.
They also work effectively on:
Polynucleotide treatments can help improve skin elasticity, reduce fine lines, and restore glow. Polynucleotides are also used to improve wound healing, stimulate hair regeneration, and support joint repair in other medical contexts.
Your treatment journey starts with a detailed consultation to assess your skin condition, age, and goals. The treatment is suitable for most people and is especially effective for ageing skin or skin that needs hydration and repair.
During the procedure, polynucleotides are injected into the skin using a very fine needle or cannula. You might experience tiny bumps at the injection site for a few hours, along with some mild redness or bruising. These potential side effects typically resolve within a day or two.
Each injectable treatment session takes about 30 minutes. To minimise discomfort, a topical numbing cream is applied before the procedure—please arrive 30 minutes early to allow adequate time for this preparation. For optimal results, we recommend a course of 2 to 3 sessions spaced 3 to 4 weeks apart, followed by maintenance treatments every 6 to 12 months, depending on skin response and age.
The benefits of polynucleotides extend beyond surface-level rejuvenation. They promote regeneration from within by enhancing fibroblast activity and collagen production. Other benefits include:
One of the most remarkable effects of polynucleotides is their ability to encourage natural skin healing. This makes them ideal as a pre- or post-surgical skin treatment and for treating acne scars or sun-damaged skin.
Polynucleotides are generally well-tolerated and have a high safety profile. Because polynucleotides are derived from purified DNA fragments, allergic reactions are extremely rare. Most clients only experience temporary redness, swelling, or minor bruising.
We always conduct a thorough consultation before your first treatment to ensure suitability. Treatments are generally safe for all skin types, though not recommended if you are pregnant, breastfeeding, or have active skin infections.
While serious side effects are rare, we always provide clear aftercare instructions and are available for follow-up support.
Over the years, Dr. Bela has identified multiple melanomas on aesthetic patients—often in areas they hadn’t noticed themselves. In one notable case, during a Botox consultation, he spotted a small but suspicious lesion on a patient’s forehead. When reviewing previous treatment photos, it became clear that the melanoma had gradually developed over time, becoming increasingly visible across sessions. Despite its small size, the lesion was already an early invasive melanoma—but was thankfully detected in time. This case is just one of several examples highlighting how melanoma can remain hidden in plain sight. For this reason, Dr. Bela now offers a discounted mole check for all existing aesthetic patients, making it easier to combine cosmetic care with life-saving early detection.
Your injectable procedure will be performed by Dr Bela, a skin and aesthetic specialist with over 14 years of cosmetic dermatology experience. Dr Bela combines advanced medical techniques with a holistic understanding of skin health to deliver safe, natural-looking results.
Most people notice improvements in skin texture and hydration within two weeks. The full effects build gradually over 6 to 8 weeks.
Results typically last 6 to 12 months. Maintenance treatments help extend and enhance the effects of polynucleotides.
Yes, polynucleotides are often used alongside Botox, Profhilo, microneedling, or laser treatment as part of a comprehensive skin rejuvenation plan.
Absolutely. Polynucleotides are injected gently into the delicate eye area and are particularly suited to treating dark circles, fine lines, and crepey texture.
Downtime is minimal. You may have slight redness or bruising at the treatment area, but this resolves quickly.
Skin boosters such as Profhilo primarily hydrate, while polynucleotides stimulate regeneration. They work well together but serve different purposes in your treatment plan.
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